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The orchestrated functions of innate leukocytes and t cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge

Tahiliani, Vikas; Chaudhri, Geeta; Eldi, Preethi; Karupiah, Gunasegaran

Description

A pivotal role for antigen-specific recall responses to secondary virus infection is well established, but the contribution of innate immune cells to this process is unknown. Recovery of mice from a primary orthopoxvirus (ectromelia virus [ECTV]) infection requires the function of natural killer (NK) cells, granulocytes, plasmacytoid dendritic cells (pDC), T cells, and B cells. However, during a secondary challenge, resolution of infection is thought to be dependent on antibody but not T cell...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/73912
Source: Journal of Virology
DOI: 10.1128/JVI.03038-12

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