Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Sabouri, Zahra; Schofield, Peter; Horikawa, Keisuke; Spierings, Emily; Kipling, David; Randall, Katrina; Langley, David; Roome, Brendan; Vazquez-Lombardi, Rodrigo; Rouet, Romain; Hermes, Jana; Chan, Tyani D; Brink, Robert; Dunn-Walters, Deborah K; Christ, Daniel; Goodnow, Christopher
The best-understood mechanisms for achieving antibody self/nonself discrimination discard self-reactive antibodies before they can be tested for binding microbial antigens, potentially creating holes in the repertoire. Here we provide evidence for a complementary mechanism: retaining autoantibodies in the repertoire displayed as low levels of IgM and high IgD on anergic B cells, masking a varying proportion of autoantibody-binding sites with carbohydrates, and removing their self-reactivity by...[Show more]
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