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Human Glutathione Transferase Zeta

Board, Philip; Anders, Michael

Description

Zeta-class glutathione transferases (GSTZs) were recently discovered by a bioinformatics approach and the availability of human expressed sequence tag databases. Although GSTZ showed little activity with conventional GST substrates (1-chloro-2,4-dinitrobenzene; organic hydroperoxides), GSTZ was found to catalyze the oxygenation of dichloroacetic acid (DCA) to glyoxylic acid and the cis-trans isomerization of maleylacetoacetate to fumarylacetoacetate. Hence, GSTZ plays a critical role in the...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Book chapter
URI: http://hdl.handle.net/1885/73850
DOI: 10.1016/S0076-6879(05)01004-9

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