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Using Deubiquitylating Enzymes as Research Tools

Baker, Rohan; Catanzariti, Ann-Maree; Karunasekara, Yamuna; Soboleva, Tatiana; Sharwood, Robert; Whitney, Spencer; Board, Philip


Ubiquitin is synthesized in eukaryotes as a linear fusion with a normal peptide bond either to itself or to one of two ribosomal proteins and, in the latter case, enhances the yield of these ribosomal proteins and/or their incorporation into the ribosome. Such fusions are cleaved rapidly by a variety of deubiquitylating enzymes. Expression of heterologous proteins as linear ubiquitin fusions has been found to significantly increase the yield of unstable or poorly expressed proteins in either...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Book chapter
DOI: 10.1016/S0076-6879(05)98044-0


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