Skip navigation
Skip navigation

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Pattabiraman, Diwakar; McGirr, Crystal; Shakhbazov, Konstantin; Barbier, Valerie; Krishnan, Keerthana; Mukhopadhyay, Pamela; Hawthorne, Paula; Trezise, Ann; Ding, Jianmin; Grimmond, Sean M.; Papathanasiou, Panagiotis; Alexander, Warren S; Perkins, Andrew C.; Levesque, Jean-Pierre; Winkler, Ingrid G.; Gonda, Thomas


The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a therapeutic target in these diseases. However, realization of this potential requires a significant therapeutic window for MYB inhibition, given its essential role in normal hematopoiesis, and an approach for developing an effective therapeutic. We previously showed that the interactionof c-MybwiththecoactivatorCBP/p300 is essential for its...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2012-02-413187


File Description SizeFormat Image
01_Pattabiraman_Interaction_of_c-Myb_with_p300_2014.pdf1.41 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator