The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: A proposal for an evolutionary driving force
Bocedi, Alessio; Fabrini, Raffaele; Farrotti, Andrea; Stella, Lorenzo; Ketterman, Albert; Pedersen, Jens Z.; Allocati, Nerino; Lau, Peter C. K.; Grosse, Stephan; Eltis, Lindsay D.; Ruzzini, Antonio; Edwards, Thomas E.; Morici, Laura; Del Grosso, Erica; Guidoni, Leonardo; Board, Philip
Description
Background: Why do ancestral GSTs utilize cysteine/serine as catalytic residues, whereas more recently evolved GSTs utilize tyrosine? Results: Only the more recently evolved GSTs display enough affinity to bind and make harmless the toxic DNDGIC (a natura
| Collections | ANU Research Publications |
|---|---|
| Date published: | 2013 |
| Type: | Journal article |
| URI: | http://hdl.handle.net/1885/73770 |
| Source: | Journal of Biological Chemistry |
| DOI: | 10.1074/jbc.M113.476135 |
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| File | Description | Size | Format | Image |
|---|---|---|---|---|
| 01_Bocedi_The_impact_of_nitric_oxide_2013.pdf | 1.96 MB | Adobe PDF | Request a copy |
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