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The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: A proposal for an evolutionary driving force

Bocedi, Alessio; Fabrini, Raffaele; Farrotti, Andrea; Stella, Lorenzo; Ketterman, Albert; Pedersen, Jens Z.; Allocati, Nerino; Lau, Peter C. K.; Grosse, Stephan; Eltis, Lindsay D.; Ruzzini, Antonio; Edwards, Thomas E.; Morici, Laura; Del Grosso, Erica; Guidoni, Leonardo; Board, Philip


Background: Why do ancestral GSTs utilize cysteine/serine as catalytic residues, whereas more recently evolved GSTs utilize tyrosine? Results: Only the more recently evolved GSTs display enough affinity to bind and make harmless the toxic DNDGIC (a natura

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M113.476135


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