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The mGlu5 receptor regulates extinction of cocaine-driven behaviours

Bird, Michael K; Lohmann, Peter; West, Billy; Brown, Robyn; Kirchhoff , Jeppe; Raymond, Clarke; Lawrence , Andrew J


Background: There is extensive evidence implicating the metabotropic glutamate 5 (mGlu5) receptor in aspects of addiction-related behaviours. Methods: Here, we used a well-characterized line of mGlu5-deficient mice to further examine the role of this receptor in cocaine-driven behaviours. We confirmed the previously reported deficit in hippocampal long-term potentiation and associated spatial learning impairment. Results: Despite a spatial learning deficit, mGlu5-deficient mice developed and...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Drug and Alcohol Dependence
DOI: 10.1016/j.drugalcdep.2014.01.017


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