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Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering

Kopecki, Zlatko; Yang, Gink N.; Arkell, Ruth; Jackson, Jessica E.; Melville, Elizabeth; Iwata, Hiroaki; Ludwig, Ralf J.; Zillikens, Detlef; Murrell, Dedee F.; Cowin, Allison J

Description

Development of an intact epidermis is critical for maintaining the integrity of the skin. Patients with epidermolysis bullosa (EB) experience multiple erosions, which breach the epidermal barrier and lead to increased microbial colocalization of wounds, infections and sepsis. The cytoskeletal protein Flightless I (Flii) is a known regulator of both development and wound healing. Using Flii+/-, WT and FliiTg/Tg mice, we investigated the effect of altering Flii levels in embryos and adult mice on...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/73755
Source: Journal of Pathology
DOI: 10.1002/path.4323

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