Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering

Kopecki, Zlatko; Yang, Gink N.; Arkell, Ruth; Jackson, Jessica E.; Melville, Elizabeth; Iwata, Hiroaki; Ludwig, Ralf J.; Zillikens, Detlef; Murrell, Dedee F.; Cowin, Allison J


Development of an intact epidermis is critical for maintaining the integrity of the skin. Patients with epidermolysis bullosa (EB) experience multiple erosions, which breach the epidermal barrier and lead to increased microbial colocalization of wounds, infections and sepsis. The cytoskeletal protein Flightless I (Flii) is a known regulator of both development and wound healing. Using Flii+/-, WT and FliiTg/Tg mice, we investigated the effect of altering Flii levels in embryos and adult mice on...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Pathology
DOI: 10.1002/path.4323


File Description SizeFormat Image
01_Kopecki_Flightless_I_over-expression_2014.pdf2.92 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator