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Oxidation of threonine residues with IBX reagents

Manohari Abeysinghe, P; Han, Yu; Harding, Margaret

Description

The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/73592
Source: Tetrahedron Letters
DOI: 10.1016/j.tetlet.2009.03.107

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