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Antitumor bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivatives

Harding, Margaret; Manohari Abeysinghe, p

Description

This Perspective will focus on recent developments in the field of antitumour metallocenes structurally related to titanocene dichloride. Despite extensive testing of titanocene dichloride which culminated in phase I and II clinical trials, further trials have been abandoned. While DNA has been implicated as the major target related to anticancer activity, identification of the active species and mechanism of action has been poorly understood and hence the design of second generation titanocene...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/73578
Source: Dalton Transactions
DOI: 10.1039/b707440a

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