Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride
The effect of aqueous solubility, charge, and lability of four thiol derivatives of the antitumor metallocene molybdocene dichloride (Cp 2MoCl2) on the cell uptake and cytotoxicity against V79 Chinese hamster lung cells has been determined. Addition of 4-thiol-2,3,5,6- tetrafluorobenzoic acid, 1-thio-β-D-glucose, and 1-thio-2,3,4,5- tetraacetyl-β-D-glucose to aqueous solutions of molybdocene dichloride afforded the corresponding metallocenes in which the deprotonated thiols are coordinated to...[Show more]
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|Source:||Journal of Medicinal Chemistry|
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