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Organometallic Anticancer Agents: Cellular Uptake and Cytotoxicity Studies on Thiol Derivatives of the Antitumor Agent Molybdocene Dichloride

Waern, Jenny B; Dillon, Carolyn; Harding, Margaret


The effect of aqueous solubility, charge, and lability of four thiol derivatives of the antitumor metallocene molybdocene dichloride (Cp 2MoCl2) on the cell uptake and cytotoxicity against V79 Chinese hamster lung cells has been determined. Addition of 4-thiol-2,3,5,6- tetrafluorobenzoic acid, 1-thio-β-D-glucose, and 1-thio-2,3,4,5- tetraacetyl-β-D-glucose to aqueous solutions of molybdocene dichloride afforded the corresponding metallocenes in which the deprotonated thiols are coordinated to...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm049585o


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