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The effect of hydrophobic analogues of the type I winter flounder antifreeze protein on lipid bilayers

Tomczak, Melanie M; Hincha, Dirk K; Crowe, John H; Harding, Margaret; Haymet, A D J


The effect of four synthetic analogues of the 37-residue winter flounder type I antifreeze protein (AFP), which contain four Val, Ala or Ile residues in place of Thr residues at positions 2, 13, 24 and 37 and two additional salt bridges, on the binary lipid system prepared from a 1:1 mixture of the highly unsaturated DGDG and saturated DMPC has been determined using FTIR spectroscopy. In contrast to the natural protein, which increases the thermotropic phase transition, the Thr, Val and Ala...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: FEBS Letters
DOI: 10.1016/s0014-5793(03)00843-3


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