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9-hydroxyellipticine and derivatives as chemotherapy agents

Grummitt, Annaleise R; Harding, Margaret

Description

The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines. Recent studies have focused on the mechanism of inhibition of phosphorylation of the mutant type of p53 protein, structural characterisation of the drug-DNA complex, the synthesis of carbohydrate derivatives...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/73538
Source: Mini-Reviews in Medicinal Chemistry
DOI: 10.2174/1389557033405377
10.2174/1389557033405377

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