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Detection of DNA via an Ion Channel Switch Biosensor

Wright Lucas, Sally; Harding, Margaret


Detection of DNA by an ion channel switch biosensor has been demonstrated in a model system, using single-stranded oligonucleotide sequences of 52-84 bases in length. Two different biotinylated probes are bound, via streptavidin, either to the outer region of a gramicidin ion channel dimer or to an immobilized membrane component. The ion channels are switched off upon detection of DNA containing complementary epitopes to these probes, separated by a nonbinding region, at nanomolar levels. The...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Analytical Biochemistry
DOI: 10.1006/abio.2000.4568


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