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Water soluble, hydrolytically stable derivatives of the antitumor drug titanocene dichloride and binding studies with nucleotides

Mokdsi, George; Harding, Margaret


The rate of hydrolysis of the aromatic rings of Cp2TiX2 and the dimethylsubstituted derivatives (MeCp)2TiX2 [X=Cl, O2CCH2NH3Cl], in aqueous solutions at pH 2-8 have been studied by 1H-NMR spectroscopy. Rapid hydrolysis of both the halide and cyclopentadienyl ligands in Cp2TiX2 [X=Cl, O2CCH2NH3Cl] occurs to give predominantly insoluble precipitates at pH 7. In contrast, under the same experimental conditions, the predominant species present in aqueous solutions of (MeCp)2TiX2 [X=Cl, O2CCH2NH3Cl]...[Show more]

CollectionsANU Research Publications
Date published: 1998
Type: Journal article
Source: Journal of Organometallic Chemistry
DOI: 10.1016/s0022-328x(98)00441-0


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