Water soluble, hydrolytically stable derivatives of the antitumor drug titanocene dichloride and binding studies with nucleotides
The rate of hydrolysis of the aromatic rings of Cp2TiX2 and the dimethylsubstituted derivatives (MeCp)2TiX2 [X=Cl, O2CCH2NH3Cl], in aqueous solutions at pH 2-8 have been studied by 1H-NMR spectroscopy. Rapid hydrolysis of both the halide and cyclopentadienyl ligands in Cp2TiX2 [X=Cl, O2CCH2NH3Cl] occurs to give predominantly insoluble precipitates at pH 7. In contrast, under the same experimental conditions, the predominant species present in aqueous solutions of (MeCp)2TiX2 [X=Cl, O2CCH2NH3Cl]...[Show more]
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|Source:||Journal of Organometallic Chemistry|
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