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Antitumor metallocenes: effect of DMSO on the stability of Cp 2 TiX 2 and implications for anticancer activity

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Harding, Margaret; Mokdsi, George

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The rate of hydrolysis of the aromatic rings of Cp2TiX2 [X = Cl 1, O2CCCl3 8 and O2CCH2NH3Cl 13], in aqueous solutions, 10% DMSO and 100% DMSO have been studied by 1H NMR spectroscopy. Rapid hydrolysis of both the carboxylate and cyclopentadienyl ligands

dc.contributor.authorHarding, Margaret
dc.contributor.authorMokdsi, George
dc.date.accessioned2015-12-13T22:26:21Z
dc.identifier.issn0793-0291
dc.identifier.urihttp://hdl.handle.net/1885/73484
dc.description.abstractThe rate of hydrolysis of the aromatic rings of Cp2TiX2 [X = Cl 1, O2CCCl3 8 and O2CCH2NH3Cl 13], in aqueous solutions, 10% DMSO and 100% DMSO have been studied by 1H NMR spectroscopy. Rapid hydrolysis of both the carboxylate and cyclopentadienyl ligands
dc.publisherHindawi Publishing Corporation
dc.sourceMetal-Based Drugs
dc.subjectKeywords: antineoplastic metal complex; dimethyl sulfoxide; titanocene dichloride; antineoplastic activity; aqueous solution; conference paper; drug hydrolysis; drug stability; proton nuclear magnetic resonance
dc.titleAntitumor metallocenes: effect of DMSO on the stability of Cp 2 TiX 2 and implications for anticancer activity
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume5
dc.date.issued1998
local.identifier.absfor111500 - PHARMACOLOGY AND PHARMACEUTICAL SCIENCES
local.identifier.ariespublicationf5625xPUB3710
local.type.statusPublished Version
local.contributor.affiliationHarding, Margaret, Administrative Division, ANU
local.contributor.affiliationMokdsi, George, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage207
local.bibliographicCitation.lastpage215
local.identifier.doi10.1155/mbd.1998.207
dc.date.updated2015-12-11T08:21:51Z
local.identifier.scopusID2-s2.0-0031698551
CollectionsANU Research Publications

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