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Interactions of the Antitumor Agent Molybdocene Dichloride with Oligonucleotides

Harding, Margaret; Mokdsi, George; Mackay, Joel Peter; Prodigalidad, Michael; Wright Lucas, Sally


The interactions between the antitumor-active metallocene molybdocene dichloride (Cp2MoCl2) and four oligonucleotides have been studied by 1H and 31P NMR spectroscopy. In 50 mM salt solutions of molybdocene dichloride, hydrolysis of the halide ligands occurs to give a solution with pD 2, containing a species in which both Cp rings remain metal bound for 24 h. At pD 7, however, partial hydrolysis of the Cp rings (∼30%) occurs after 24 h. Addition of an aqueous solution of molybdocene dichloride...[Show more]

CollectionsANU Research Publications
Date published: 1998
Type: Journal article
Source: Inorganic Chemistry
DOI: 10.1021/ic971205k


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