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DNA-binding studies of XSPTSPSZ, derivatives of the intercalating heptad repeat of RNA polymerase II

Harding, Margaret; Krippner, Guy Y; Shelton, Cathryn J; Rodger, Alison; Sanders, Karen J; Mackay, Joel Peter; Prakash, Arungundrum S

Description

The synthesis, solution conformation, and interaction with DNA of three 8-residue peptides structurally related to the heptad repeat unit found at the C-terminus of RNA polymerase II are reported. Peptides QQ, XQ, and PQ are derived from the parent sequence YSPTSPSY (peptide YY), which was reported to bind to DNA by bisintercalation [M. Suzuki (1990) Nature, Vol. 344, pp. 562- 565], and contain either a 2-quinolyl (Q), 2-quinoxolyl (X), or 5- phenanthrolyl (P) group in place of the aromatic...[Show more]

CollectionsANU Research Publications
Date published: 1997
Type: Journal article
URI: http://hdl.handle.net/1885/73465
Source: Biopolymers
DOI: 10.1002/(sici)1097-0282(19971005)42:4<387::aid-bip2>3.0.co;2-m

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