DNA-binding studies of XSPTSPSZ, derivatives of the intercalating heptad repeat of RNA polymerase II
The synthesis, solution conformation, and interaction with DNA of three 8-residue peptides structurally related to the heptad repeat unit found at the C-terminus of RNA polymerase II are reported. Peptides QQ, XQ, and PQ are derived from the parent sequence YSPTSPSY (peptide YY), which was reported to bind to DNA by bisintercalation [M. Suzuki (1990) Nature, Vol. 344, pp. 562- 565], and contain either a 2-quinolyl (Q), 2-quinoxolyl (X), or 5- phenanthrolyl (P) group in place of the aromatic...[Show more]
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