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Characterization of the human Omega class glutathione transferase genes and associated polymorphisms

Whitbread, Astrid; Tetlow, Natasha; Eyre, Helen; Sutherland, Grant; Board, Philip


The Omega class glutathione transferases (GSTs) have been identified in many organisms, including human, mouse, rat, pig, Caenorhabditis elegans and Drosophila melanogaster. These GSTs have poor activity with common GST substrates, but exhibit novel glutathione-dependent thioltransferase, dehydroascorbate reductase and monomethylarsonate reductase activities, and modulate Ca2+ release by ryanodine receptors. An investigation of the genomic organization of human GSTO1 identified a second...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Pharmacogenetics and Genomics
DOI: 10.1097/00008571-200303000-00003


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