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The fast gating mechanism in ClC-0 channels

Bisset, David; Corry, Ben; Chung, Shin-Ho


We investigate and then modify the hypothesis that a glutamate side chain acts as the fast gate in ClC-0 channels. We first create a putative open-state configuration of the prokaryotic ClC Cl- channel using its crystallographic structure as a basis. Then, retaining the same pore shape, the prokaryotic ClC channel is converted to ClC-0 by replacing all the nonconserved polar and charged residues. Using this open-state channel model, we carry out molecular dynamics simulations to study how the...[Show more]

CollectionsANU Research Publications
Date published: 2005-07
Type: Journal article
Source: Biophysical Journal
DOI: 10.1529/biophysj.104.053447


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