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Human malarial disease: a consequence of inflammatory cytokine release

Clark, Ian A; Budd, Alison; Alleva, Lisa M; Cowden, William B


Malaria causes an acute systemic human disease that bears many similarities, both clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the past few decades, a literature has emerged that argues for most of the pathology seen in all of these infectious diseases being explained by activation of the inflammatory system, with the balance between the pro and anti-inflammatory cytokines being tipped towards the onset of systemic inflammation. Although not often...[Show more]

CollectionsANU Research Publications
Date published: 2006-10-10
Type: Journal article
Source: Malaria Journal
DOI: 10.1186/1475-2875-5-85
Access Rights: Open Access


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