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The Phosphoinositide 3-Kinase and p70 S6 Kinase Regulate Long-Term Potentiation in Hippocampal Neurons

Raymond, Clarke; Redman, Stephen; Crouch, Michael F

Description

The mechanisms by which long-term changes in synaptic efficacy (e.g., long-term potentiation) are maintained are not well understood. There is evidence that reorganization of the neuronal actin cytoskeleton is important for consolidation of long-term potentiation. In non-neuronal cells, phosphoinositide 3-kinase and p70 S6 kinase have been shown to regulate actin polymerization. We have investigated the subcellular localization of these enzymes in cultured hippocampal pyramidal neurons and...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/73341
Source: Neuroscience
DOI: 10.1016/S0306-4522(01)00500-0

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