The Phosphoinositide 3-Kinase and p70 S6 Kinase Regulate Long-Term Potentiation in Hippocampal Neurons
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Raymond, Clarke; Redman, Stephen; Crouch, Michael F
Description
The mechanisms by which long-term changes in synaptic efficacy (e.g., long-term potentiation) are maintained are not well understood. There is evidence that reorganization of the neuronal actin cytoskeleton is important for consolidation of long-term potentiation. In non-neuronal cells, phosphoinositide 3-kinase and p70 S6 kinase have been shown to regulate actin polymerization. We have investigated the subcellular localization of these enzymes in cultured hippocampal pyramidal neurons and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2002 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/73341 |
Source: | Neuroscience |
DOI: | 10.1016/S0306-4522(01)00500-0 |
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01_Raymond_The_Phosphoinositide_3-Kinase_2002.pdf | 328.36 kB | Adobe PDF | Request a copy |
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