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Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition

Delerue, Fabien; Sjollema, Geoffrey; Whittle, Belinda; Kruger, Sarah; Andrews, Dan; Gotz, Jurgen

Description

One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of se

dc.contributor.authorDelerue, Fabien
dc.contributor.authorSjollema, Geoffrey
dc.contributor.authorWhittle, Belinda
dc.contributor.authorKruger, Sarah
dc.contributor.authorAndrews, Dan
dc.contributor.authorGotz, Jurgen
dc.date.accessioned2015-12-13T22:25:22Z
dc.identifier.issn2090-0252
dc.identifier.urihttp://hdl.handle.net/1885/73208
dc.description.abstractOne of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of se
dc.publisherHindawi Publishing Corporation
dc.rightsAuthor/s retain copyright
dc.sourceInternational Journal of Alzheimer's Disease
dc.subjectKeywords: aging; Alzheimer disease; animal experiment; animal model; animal tissue; article; brain dysfunction; controlled study; exome; gene mutation; gene sequence; genotype; immune dysregulation; lifespan; mouse; nerve degeneration; nonhuman; phenotype; priority Alzheimer's disease; exome sequencing; mouse; senescence; sequence nucleotide variants
dc.titleSingle nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume36
dc.date.issued2013
local.identifier.absfor100109 - Transgenesis
local.identifier.absfor110700 - IMMUNOLOGY
local.identifier.ariespublicationf5625xPUB3601
local.type.statusPublished Version
local.contributor.affiliationDelerue, Fabien, University of Sydney
local.contributor.affiliationSjollema, Geoffrey, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWhittle, Belinda, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKruger, Sarah, University of Sydney
local.contributor.affiliationAndrews, Dan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGotz, Jurgen, University of Sydney
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage349
local.bibliographicCitation.lastpage363
local.identifier.doi10.3233/JAD-130089
dc.date.updated2016-02-24T09:14:22Z
local.identifier.scopusID2-s2.0-84879659939
local.identifier.thomsonID000320537700014
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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