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Hypoxia and persistent sodium current

Hammarstrom, Anna; Gage, Peter

Description

During prolonged depolarization of excitable cells, some voltage-activated, tetrodotoxin-sensitive sodium channels are resistant to inactivation and can continue to open for long periods of time, generating a "persistent" sodium current (INaP). The amplitude of INaP is small [generally less than 1% of the peak amplitude of the transient sodium current (INaT)], activates at potentials close to the resting membrane potential, and is more sensitive to Na channel blocking drugs than INaT. It is...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/73198
Source: European Biophysics Journal
DOI: 10.1007/s00249-002-0218-2

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