Hypoxia and persistent sodium current
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Hammarstrom, Anna; Gage, Peter
Description
During prolonged depolarization of excitable cells, some voltage-activated, tetrodotoxin-sensitive sodium channels are resistant to inactivation and can continue to open for long periods of time, generating a "persistent" sodium current (INaP). The amplitude of INaP is small [generally less than 1% of the peak amplitude of the transient sodium current (INaT)], activates at potentials close to the resting membrane potential, and is more sensitive to Na channel blocking drugs than INaT. It is...[Show more]
Collections | ANU Research Publications |
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Date published: | 2002 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/73198 |
Source: | European Biophysics Journal |
DOI: | 10.1007/s00249-002-0218-2 |
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01_Hammarstrom_Hypoxia_and_persistent_sodium_2002.pdf | 129 kB | Adobe PDF | Request a copy |
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