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Alphavirus 6K proteins form ion channels

Melton, Julian; Ewart, Gary; Weir, Ron; Board, Philip; Lee, Eva; Gage, Peter


Ross River virus and Barmah Forest virus are Australian arboviruses of the Alphavirus genus. Features of alphavirus infection include an increased permeability of cells to monovalent cations followed by virion budding. Virally encoded ion channels are thought to have a role in these processes. In this paper, the 6K proteins of Ross River virus and Barmah Forest virus are shown to form cation-selective ion channels in planar lipid bilayers. Using a novel purification method, bacterially...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M207847200


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