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Structural Investigation of the Hedamycin:d(ACCGGT) 2 Complex by NMR and Restrained Molecular Dynamics

Owen, Elisabeth; Burley, Glenn; Carver, John; Wickham, Geoffrey; Keniry, Max

Description

Hedamycin, a member of the pluramycin family of drugs, displays a range of biological responses including antitumor and antimicrobial activity. The mechanism of action is via direct interaction with DNA through intercalation between the bases of the oligonucleotide and alkylation of a guanine residue at 5′-PyG-3′ sites. There appears to be some minor structural differences between two earlier studies on the interaction of hedamycin with 5′-PyG-3′ sites. In this study, a high-resolution NMR...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/73107
Source: Biochemical and Biophysical Research Communications
DOI: 10.1006/bbrc.2002.6369

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