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Structural Basis for Proofreading during Replication of the Escherichia coli Chromosome

Hamdan, Samir; Carr, Paul D; Brown, Susan Elizabeth; Ollis, David; Dixon, Nicholas

Description

The ε subunit of the Escherichia coli replicative DNA polymerase III is the proofreading 3′-5′ exonuclease. Structures of its catalytic N-terminal domain (ε186) were determined at two pH values (5.8 and 8.5) at resolutions of 1.7-1.8 Å, in complex

dc.contributor.authorHamdan, Samir
dc.contributor.authorCarr, Paul D
dc.contributor.authorBrown, Susan Elizabeth
dc.contributor.authorOllis, David
dc.contributor.authorDixon, Nicholas
dc.date.accessioned2015-12-13T22:25:07Z
dc.identifier.issn0969-2126
dc.identifier.urihttp://hdl.handle.net/1885/73097
dc.description.abstractThe ε subunit of the Escherichia coli replicative DNA polymerase III is the proofreading 3′-5′ exonuclease. Structures of its catalytic N-terminal domain (ε186) were determined at two pH values (5.8 and 8.5) at resolutions of 1.7-1.8 Å, in complex
dc.publisherCell Press
dc.sourceStructure
dc.subjectKeywords: DNA directed DNA polymerase gamma; exonuclease; manganese; thymidine phosphate; water; article; bacterial chromosome; chromosome replication; DNA protein complex; DNA replication; Escherichia coli; pH; priority journal; protein structure; Amino Acid Seque Binuclear metallohydrolase; DNA polymerase III; DNA replication; DnaQ; Exonuclease (3'-5'); Manganese metalloenzyme; X-ray crystallography
dc.titleStructural Basis for Proofreading during Replication of the Escherichia coli Chromosome
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume10
dc.date.issued2002
local.identifier.absfor030505 - Physical Organic Chemistry
local.identifier.ariespublicationMigratedxPub3554
local.type.statusPublished Version
local.contributor.affiliationHamdan, Samir, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCarr, Paul D, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBrown, Susan Elizabeth, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOllis, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDixon, Nicholas, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage535
local.bibliographicCitation.lastpage546
local.identifier.doi10.1016/S0969-2126(02)00738-4
dc.date.updated2015-12-11T08:13:21Z
local.identifier.scopusID2-s2.0-0036229246
CollectionsANU Research Publications

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