Brooks, Andrew J; Johansson, Magnus; John, Anna; Xu, Yibin; Jans, David A; Vasudevan, Subhash
Dengue virus NS5 protein is a multifunctional RNA-dependent RNA polymerase that is essential for virus replication. We have shown previously that the 37-amino acid interdomain spacer sequence (residues369X2KKX14KKKX11 RKX3405) of Dengue2 NS5 contains a functional nuclear localization signal (NLS). In this study, β-galactosidase fusion proteins carrying point mutations of the positively charged residues or truncations of the interdomain linker region (residues 369-389 or residues 386-405) were...[Show more]
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