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Solution Structure of mu-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels

Nielsen, Katherine; Watson, Michael; Adams, David; Hammarstrom, Anna; Gage, Peter; Hill, James O; Craik, David J; Thomas, Linda; Adams, Denise; Alewood, Paul F; Lewis, Richard L


μ-Conotoxins are peptide inhibitors of voltage-sensitive sodium channels (VSSCs). Synthetic forms of μ-conotoxins PIIIA and PIIIA-(2-22) were found to inhibit tetrodotoxin (TTX)-sensitive VSSC current but had little effect on TTX-resistant VSSC current

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M201611200


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