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Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis

Mullbacher, Arno; Lobigs, Mario; Tha Hla, Ron; Tran, Thao (Thomas); Stehle, Thomas; Simon, Markus M


Effector cytolytic T (Tc) lymphocytes, deficient in the exocytosis-mediated pathway of target cell lysis, induce Fas on target cells and, in turn, delayed cell death and apoptosis via the Fas ligand-Fas interaction. The induction of Fas can be blocked by

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Immunology


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