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Intrinsic Defect in T Cell Production of Interleukin (1L)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

Mattes, Joerg; Yang, Ming; Mahalingam, Surendran; Kuehr, Joachim; Webb, Dianne; Simson, Ljubov; Hogan, Simon; Koskinen, Aulikki; Mckenzie, Andrew N; Dent, Lindsay; Rothenberg, Marc E; Matthaei, Klaus; Young, Ian; Foster, Paul S

Description

Interleukin (IL)-5 and IL-13 are thought to play key roles in the pathogenesis of asthma. Although both cytokines use eotaxin to regulate eosinophilia, IL-13 is thought to operate a separate pathway to IL-5 to induce airways hyperreactivivy, (AHR) in the

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/72949
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20020009

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