Skip navigation
Skip navigation
The system will be down for maintenance between 8:00 and 8:15am on Thursday 13, December 2018

Complex structures between the N-type calcium channel (CaV2.2) and I-Conotoxin GVIA predicted via molecular dynamics

Chung, Shin-Ho; Chen, Rong

Description

The N-type voltage-gated Ca2+ channel CaV2.2 is one of the important targets for pain management. ω-Conotoxins isolated from venoms of cone snails, which specifically inhibit CaV2.2, are promising scaffolds for novel analgesics. The inhibitory action of

dc.contributor.authorChung, Shin-Ho
dc.contributor.authorChen, Rong
dc.date.accessioned2015-12-13T22:24:39Z
dc.identifier.issn0003-2697
dc.identifier.urihttp://hdl.handle.net/1885/72823
dc.description.abstractThe N-type voltage-gated Ca2+ channel CaV2.2 is one of the important targets for pain management. ω-Conotoxins isolated from venoms of cone snails, which specifically inhibit CaV2.2, are promising scaffolds for novel analgesics. The inhibitory action of
dc.publisherAcademic Press
dc.sourceAnalytical Biochemistry
dc.subjectKeywords: Aspartate residue; Complex structure; Inhibitory concentration; Ion-conduction pathways; Molecular dynamics simulations; Potential of mean force; Selectivity filter; Umbrella sampling; Binding energy; Molecular dynamics; Plants (botany); Scaffolds; Toxic
dc.titleComplex structures between the N-type calcium channel (CaV2.2) and I-Conotoxin GVIA predicted via molecular dynamics
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume52
dc.date.issued2013
local.identifier.absfor030100 - ANALYTICAL CHEMISTRY
local.identifier.ariespublicationf5625xPUB3443
local.type.statusPublished Version
local.contributor.affiliationChung, Shin-Ho, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChen, Rong, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue21
local.bibliographicCitation.startpage3765
local.bibliographicCitation.lastpage3772
local.identifier.doi10.1021/bi4003327
dc.date.updated2016-02-24T09:10:59Z
local.identifier.scopusID2-s2.0-84878306447
local.identifier.thomsonID000319795500018
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Chung_Complex_structures_between_the_2013.pdf2 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  27 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator