Complex structures between the N-type calcium channel (CaV2.2) and I-Conotoxin GVIA predicted via molecular dynamics
The N-type voltage-gated Ca2+ channel CaV2.2 is one of the important targets for pain management. ω-Conotoxins isolated from venoms of cone snails, which specifically inhibit CaV2.2, are promising scaffolds for novel analgesics. The inhibitory action of
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