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A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

Ahmed, Jehangir; Ali, Radiya; Warr, Nicholas; Wilson, Heather; Bellchambers, Helen; Barratt, Kristen; Thompson, Amelia; Arkell, Ruth


The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-co

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Disease Models and Mechanisms
DOI: 10.1242/dmm.011668


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