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Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle

Dulhunty, Angela; Haarmann, Claudia; Green, Daniel; Laver, Derek Rowland; Board, Philip; Casarotto, Marco

Description

Excitation-contraction coupling in both skeletal and cardiac muscle depends on structural and functional interactions between the voltage-sensing dihydropyridine receptor L-type Ca2+ channels in the surface/transverse tubular membrane and ryanodine receptor Ca2+ release channels in the sarcoplasmic reticulum membrane. The channels are targeted to either side of a narrow junctional gap that separates the external and internal membrane systems and are arranged so that bi-directional structural...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/72669
Source: Progress in Biophysics and Molecular Biology
DOI: 10.1016/S0079-6107(02)00013-5

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