Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle
Excitation-contraction coupling in both skeletal and cardiac muscle depends on structural and functional interactions between the voltage-sensing dihydropyridine receptor L-type Ca2+ channels in the surface/transverse tubular membrane and ryanodine receptor Ca2+ release channels in the sarcoplasmic reticulum membrane. The channels are targeted to either side of a narrow junctional gap that separates the external and internal membrane systems and are arranged so that bi-directional structural...[Show more]
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|Source:||Progress in Biophysics and Molecular Biology|
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