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C. elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms

Duan, Guowen (Tony); Saint, Robert B; Helliwell, Christopher Andrew; Behm, Carolyn; Wang, Ming-Bo; Waterhouse, Peter M.; Gordon, Karl H J

Description

Drosophila possesses the core gene silencing machinery but, like all insects, lacks the canonical RNA-dependent RNA polymerases (RdRps) that in C. elegans either trigger or enhance two major small RNA-dependent gene silencing pathways. Introduction of two

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/72564
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-012-1218-8

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