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Susceptibility of Msh2 -deficient mice to inflammation-associated colorectal tumors

Kohonen-Corish, M K; Daniel, Joseph J; te Riele, H; Buffinton, Gary; Dahlstrom, Jane


Patients with longstanding extensive ulcerative colitis have an increased risk of developing colorectal cancer (CRC). There are significant differences in the early pathogenesis of colitis-associated tumors compared with common CRC, whereas the frequency, degree, and significance of microsatellite instability (MSI) as a marker of mismatch repair deficiency in colitis tumors remain unclear. Here we describe the application of the DSS model of chronic colitis to mice with a defect in the Msh2...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Cancer Research


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