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Fibroblast-specific upregulation of Flightless I impairs wound healing

Turner, Christopher T.; Waters, James M.; Jackson, Jessica E.; Arkell, Ruth; Cowin, Allison

Description

The cytoskeletal protein Flightless (Flii) is a negative regulator of wound healing. Upregulation of Flii is associated with impaired migration, proliferation and adhesion of both fibroblasts and keratinocytes. Importantly, Flii translocates from the cytoplasm to the nucleus in response to wounding in fibroblasts but not keratinocytes. This cell-specific nuclear translocation of Flii suggests that Flii may directly regulate gene expression in fibroblasts, providing one potential mechanism of...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/72443
Source: Experimental Dermatology
DOI: 10.1111/exd.12751

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