Exploiting multiple nucleophilic sites on pyrrole for the assembly of polyheterocyclic frameworks: application to a formal total synthesis of (±)-aspidospermidine
The tricyclic ketone 19, an advanced intermediate in Aubé's recently reported synthesis of aspidospermidine (4), is prepared in twelve steps from pyrrole (3). The key transformations involve a previously described intramolecular Michael addition reaction
|Collections||ANU Research Publications|
|Source:||Journal of the Chemical Society, Perkin Transactions 1|
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