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The effect of alpha-lipoic acid on mitochondrial superoxide and glucocorticoid-induced hypertension

Ong, Lee Lin (Sharon); Vohra, Harpreet; Zhang, Yi; Sutton, Matthew; Whitworth, Judith


Aims. To examine the effect of alpha-lipoic acid, an antioxidant with mitochondrial superoxide inhibitory properties, on adrenocorticotrophic hormone- (ACTH-HT) and dexamethasone-induced hypertensions (DEX-HT) in rats and if any antihypertensive effect is mediated via mitochondrial superoxide inhibition. Methods. In a prevention study, rats received ground food or alpha-lipoic-acid-laced food (10 mg/rat/day) for 15 nights. Saline, adrenocorticotrophic hormone (ACTH, 0.2 mg/kg/day), or...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Oxidative Medicine and Cellular Longevity
DOI: 10.1155/2013/517045


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