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Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

Haczeyni, Fahrettin; Barn, Vanessa; Mridha, Auvro; Yeh, Matthew; Estevez, Emma; Febbraio, Mark; Nolan, Christopher; Bell-Anderson, Kim S; Teoh, Narcissus; Farrell, Geoffrey

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Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose function and inflammation are less clear. Accordingly, it was hypothesized that exercise improves adipose morphometry to reduce adipose inflammation in hyperphagic obese mice. Methods Alms1 mutant foz/foz mice housed in pairs were fed an atherogenic or chow diet; half the cages were fitted with a computer-monitored wheel for voluntary...[Show more]

dc.contributor.authorHaczeyni, Fahrettin
dc.contributor.authorBarn, Vanessa
dc.contributor.authorMridha, Auvro
dc.contributor.authorYeh, Matthew
dc.contributor.authorEstevez, Emma
dc.contributor.authorFebbraio, Mark
dc.contributor.authorNolan, Christopher
dc.contributor.authorBell-Anderson, Kim S
dc.contributor.authorTeoh, Narcissus
dc.contributor.authorFarrell, Geoffrey
dc.date.accessioned2015-12-13T22:22:42Z
dc.identifier.issn1930-7381
dc.identifier.urihttp://hdl.handle.net/1885/72377
dc.description.abstractObjective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose function and inflammation are less clear. Accordingly, it was hypothesized that exercise improves adipose morphometry to reduce adipose inflammation in hyperphagic obese mice. Methods Alms1 mutant foz/foz mice housed in pairs were fed an atherogenic or chow diet; half the cages were fitted with a computer-monitored wheel for voluntary exercise. Insulin-induced AKT-phosphorylation, adipocyte size distribution, and inflammatory recruitment were studied in visceral versus subcutaneous depots, and severity of fatty liver disease was determined. Results Exercise prevented obesity and diabetes development in chow-fed foz/foz mice and delayed their onset in atherogenic-fed counterparts. Insulin-stimulated phospho-AKT levels in muscle were improved with exercise, but not in adipose or liver. Exercise suppressed adipose inflammatory recruitment, particularly in visceral adipose, associated with an increased number of small adipocyte subpopulations, and enhanced expression of beige adipocyte factor PRDM16 in subcutaneous fat. In atherogenic-fed foz/foz mice liver, exercise suppressed development of nonalcoholic steatohepatitis and related liver fibrosis. Conclusions Exercise confers metabo-protective effects in atherogenic-fed hyperphagic mice by preventing early onset of obesity and diabetes in association with enhanced muscle insulin sensitivity, improved adipose morphometry, and suppressed adipose and liver inflammation.
dc.publisherNature Publishing Group
dc.sourceObesity
dc.titleExercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume23
dc.date.issued2015
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor110307 - Gastroenterology and Hepatology
local.identifier.ariespublicationa383154xPUB3216
local.type.statusPublished Version
local.contributor.affiliationHaczeyni, Fahrettin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBarn, Vanessa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMridha, Auvro, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationYeh, Matthew, University of Washington
local.contributor.affiliationEstevez, Emma, Baker IDI Heart and Diabetes Institute
local.contributor.affiliationFebbraio, Mark, Baker IDI Heart and Diabetes Institute
local.contributor.affiliationNolan, Christopher, Canberra Hospital
local.contributor.affiliationBell-Anderson, Kim S, University of Sydney
local.contributor.affiliationTeoh, Narcissus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFarrell, Geoffrey, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage1845
local.bibliographicCitation.lastpage1855
local.identifier.doi10.1002/oby.21170
dc.date.updated2015-12-11T07:58:17Z
local.identifier.scopusID2-s2.0-84940450035
CollectionsANU Research Publications

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