Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice
Haczeyni, Fahrettin; Barn, Vanessa; Mridha, Auvro; Yeh, Matthew; Estevez, Emma; Febbraio, Mark; Nolan, Christopher; Bell-Anderson, Kim S; Teoh, Narcissus; Farrell, Geoffrey
Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose function and inflammation are less clear. Accordingly, it was hypothesized that exercise improves adipose morphometry to reduce adipose inflammation in hyperphagic obese mice. Methods Alms1 mutant foz/foz mice housed in pairs were fed an atherogenic or chow diet; half the cages were fitted with a computer-monitored wheel for voluntary...[Show more]
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