Expression of the Serine/Threonine Kinase hSGK1 in Chronic Viral Hepatitis
Fillon, S; Klingel, Karen; Warntges, Simone; Sauter, Martina; Gabrysch, S; Pestel, Sabine; Tanneur, Valerie; Waldegger, S; Zipfel, Annette; Viebahn, R; Haussinger, D; Broer, Stefan; Kandolf, Reinhart; Lang, Florian
The human serine/threonine kinase hSGK1 is expressed ubiquitously with highest transcript levels in pancreas and liver. This study has been performed to determine the hSGK1 distribution in normal liver and its putative role in fibrosing liver disease. HSGK1-localization was determined by in situ hybridization, regulation of hSGK1-transcription by Northern blotting, fibronectin synthesis and hSGK1 phosphorylation by Western blotting. In normal liver hSGK1 was mainly transcribed by Kupffer cells....[Show more]
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|Source:||Cellular Physiology and Biochemistry|
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