Skip navigation
Skip navigation

DNAzyme Targeting c-jun Suppresses Skin Cancer Growth

Cai, Hong; Santiago, Fernando; Prado-Lourenco, Leonel; Wang, Bo; Patrikakis, Margaret; Davenport, Miles P.; Maghzal, Ghassan J.; Stocker, Roland; Parish, Christopher; Chong, Beng; Lieschke, Graham J.; Wong, Tak-Wah; Chesterman, Colin; Francis, Douglas J; Moloney, Fergal J.; Barnetson, Ross St.C.; Halliday, Gary M.; Khachigian, Levon M


Worldwide, one in three cancers is skin-related, with increasing incidence in many populations. Here, we demonstrate the capacity of a DNAzyme-targeting c-jun mRNA, Dz13, to inhibit growth of two common skin cancer types - basal cell and squamous cell carcinomas - in a therapeutic setting with established tumors. Dz13 inhibited tumor growth in both immunodeficient and immunocompetent syngeneic mice and reduced lung nodule formation in a model of metastasis. In addition, Dz13 suppressed...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Science Translational Medicine
DOI: 10.1126/scitranslmed.3003960


File Description SizeFormat Image
01_Cai_DNAzyme_Targeting_c-jun_2012.pdf2.06 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator