Prion channel proteins and their role in vacuolation and neurodegenerative diseases
The prion encephalopathies, which are characterized by neuropathological changes that include vacuolation, astrocytosis, the development of amyloid plaques and neuronal loss, are associated with the conversion of a normal cellular isoform of prion protein (PrPc) to an abnormal pathologic scrapie isoform (PrPSc). The use of PrP[106-126] and its isoforms in studies of channels in lipid bilayers has revealed that it forms heterogeneous channels reflecting modifications in the peptide's structure...[Show more]
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|Source:||European Biophysics Journal|
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