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A Randomized Trial to Assess Safety and Immunogenicity of Alternative Formulations of a Quadrivalent Meningococcal (A, C, Y, and W-135) Tetanus Protein Conjugate Vaccine in Toddlers

McVernon, Jodie; Nolan, Terry; Richmond, Peter; Reynolds, Graham; Nissen, Michael; Lambert, Stephen B; Marshall, Helen; Papa, Thomas; Rehm, Christine

Description

Background: Neisseria meningitidis is a leading cause of meningitis and septicemia globally. Recent shifts in serogroup dominance in some settings highlight the desirability of polysaccharide-conjugate vaccines with broader meningococcal coverage than serogroup C vaccines in widespread use. Methods: We assessed the safety and immunogenicity of a single dose of meningococcal quadrivalent (A, C, W-135, Y) tetanus conjugate vaccine (TetraMen-T), administered at 1 year of age. A total of 378...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/72117
Source: The Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0b013e31823e1e34

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