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Recent progress and future potential for metal complexes as anticancer drugs targeting G-quadruplex DNA

Li, Hongdong; Zhang, J.; Zhang, F.; Liu, C.; Xia, J; Ma, L.; Chu, W; Zhang, Z; Chen, C.; Li, S.; Wang, S.


Now cisplatin and its analogs are some of the most effective chemotherapeutic agents in clinical use as the first line of treatment in testicular and ovarian cancers. Unfortunately, they have several major drawbacks, such as cumulative toxicities of nephrotoxicity and ototoxicity, inherent or treatment-induced resistance. This has provided the motivation for developing novel metal complexes as anticancer agents with different mechanism of action. In recent years, significant attention has been...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Current Medicinal Chemistry


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