Recent progress and future potential for metal complexes as anticancer drugs targeting G-quadruplex DNA
Now cisplatin and its analogs are some of the most effective chemotherapeutic agents in clinical use as the first line of treatment in testicular and ovarian cancers. Unfortunately, they have several major drawbacks, such as cumulative toxicities of nephrotoxicity and ototoxicity, inherent or treatment-induced resistance. This has provided the motivation for developing novel metal complexes as anticancer agents with different mechanism of action. In recent years, significant attention has been...[Show more]
|Collections||ANU Research Publications|
|Source:||Current Medicinal Chemistry|
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