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Hypertonic fluid administration in patients with septic shock: A prospective randomized controlled pilot study

Van Haren, Frank; Sleigh, J; Boerma, Christiaan; La Pine, Mary; Bahr, Mohamed; Picckers, Peter; van der Hoeven, Johannes G


We assessed the short-term effects of hypertonic fluid versus isotonic fluid administration in patients with septic shock. This was a double-blind, prospective randomized controlled trial in a 15-bed intensive care unit. Twenty-four patients with septic shock were randomized to receive 250 mL 7.2% NaCl/6% hydroxyethyl starch (HT group) or 500 mL 6% hydroxyethyl starch (IT group). Hemodynamic measurements included mean arterial blood pressure (MAP), central venous pressure, stroke volume index,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Shock
DOI: 10.1097/SHK.0b013e31823f152f


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