Hu, Jie; Song, Xin; He, Yi Qing; Freeman, Craig; Parish, Christopher; Yuan, Ling; Yu , HongHua; Tang , Shibo
PURPOSE. Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal neovascularization. METHODS. C57BL/6 oxygen-induced retinopathy (OIR) mice and human retinal microvascular endothelial cells (HRECs) were treated with the hypoxia mimetic agent cobalt chloride (CoCl2), and in the presence of the heparanase inhibitor phosphomannopentaose sulfate (Muparfostat, PI-88)....[Show more]
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