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Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization

Hu, Jie; Song, Xin; He, Yi Qing; Freeman, Craig; Yuan, Ling; Yu, HongHua; Tang, Shibo; Parish, Christopher


PURPOSE. Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal neovascularization. METHODS. C57BL/6 oxygen-induced retinopathy (OIR) mice and human retinal microvascular endothelial cells (HRECs) were treated with the hypoxia mimetic agent cobalt chloride (CoCl2), and in the presence of the heparanase inhibitor phosphomannopentaose sulfate (Muparfostat, PI-88)....[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.11-9144
Access Rights: Open Access


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