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Recent Advances in Ion Channel Research

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Chung, Shin-Ho; Kuyucak, Serdar

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The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the...[Show more]

dc.contributor.authorChung, Shin-Ho
dc.contributor.authorKuyucak, Serdar
dc.date.accessioned2015-12-13T22:18:22Z
dc.identifier.issn0006-3002
dc.identifier.urihttp://hdl.handle.net/1885/71612
dc.description.abstractThe field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulations of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels.
dc.publisherElsevier
dc.sourceBiochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
dc.subjectKeywords: calcium channel; calcium channel L type; calcium ion; gramicidin A; ion channel; membrane protein; potassium channel; sodium ion; calculation; computer simulation; crystal structure; crystallization; geometry; ion permeability; molecular dynamics; molecul Brownian dynamics; Channel modeling; Membrane ion channel; Molecular dynamics; Theories of ion permeation
dc.titleRecent Advances in Ion Channel Research
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume1565
dc.date.issued2002
local.identifier.absfor029902 - Complex Physical Systems
local.identifier.ariespublicationMigratedxPub2795
local.type.statusPublished Version
local.contributor.affiliationChung, Shin-Ho, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKuyucak, Serdar, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage267
local.bibliographicCitation.lastpage286
local.identifier.doi10.1016/S0005-2736(02)00574-6
dc.date.updated2015-12-11T07:43:00Z
local.identifier.scopusID2-s2.0-0037064260
CollectionsANU Research Publications

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